Sickle cell disease (SCD) altered CD8+ T-cell chromatin architecture, triggering ferroptosis and weakening antitumor immunity. Hydrogen sulfide (H2S) treatment restored chromatin interactions and ...
Scientists have discovered how two transcription factors form a reciprocal regulatory circuit that controls T-cell exhaustion ...
Using a variety of laboratory and animal models, the team found that cysteine fuels the production of the antioxidant ...
CD8 + cytotoxic T lymphocytes (CTLs) serve as central effectors in cancer immunotherapy by directly eliminating tumor cells. However, current clinical therapies face significant limitations. These ...
A research team from the Johns Hopkins Kimmel Cancer Center, its Bloomberg~Kimmel Institute for Cancer Immunotherapy and the ...
Researchers at the Max Delbrück Center and the University of Oxford have found that a cellular housekeeping function called autophagy—by which cell components are broken down and recycled—plays a ...
Immunity is orchestrated by two responses referred to as the innate and adaptive immune systems. Each system works to ...
Meet the Jekyll and Hyde of the immune system: activated CD8⁺ T cells. On June 24 in Nature Immunology, researchers led by Dorian McGavern at the National Institutes of Health introduce a granzyme ...
A team of researchers at the Georgia Institute of Technology and Emory University has developed a deep-ultraviolet (UV) ...
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