What are spherical nucleic acids (SNAs)? What do they consist of and how do they differ from linear nucleic acids? Spherical nucleic acids are structures that are made by taking a nanoparticle ...

The intracellular environment is highly compartmentalized; biomolecules (nucleic acids, proteins, lipids and so on) are spatiotemporally organized to form functional modules, signal pathways and ...

Endosomal and cytosolic nucleic acid receptors sense microbial nucleic acids and initiate innate immune responses. However, in some circumstances their activation by endogenous nucleic acids can also ...

DNA is the poster child for high-specificity binding. As long as their base sequences match, two complementary strands of DNA can navigate through a sea of biomolecules, find each other, and hold fast ...

Nucleic acid extraction is a fundamental step in unlocking the genetic information contained within biological samples. Isolated nucleic acids are the basis for a multitude of analyses and ...

Biocompatible silicon nanoneedles, which can efficiently deliver nucleic acids and nanoparticles into biological cells without damaging them, have been developed by an international team of ...

Some biologists have long hoped that small pieces of RNA that silence genes could help wipe out genetic diseases. But developing nucleic acid medications with good drug properties, such as selectivity ...

CRISPR has the power to correct genetic mutations, but current delivery methods are either unsafe or inefficient, keeping the technology from reaching its full medical potential. With the power to ...

Nucleic acids such as DNA and RNA play a central role in gene therapies and vaccines. They store and transmit biological ...

The research focus of the Müller group is the bioinorganic chemistry of nucleic acids with a particular emphasis on the generation, characterization as well as application of nucleic acids including ...

In this Innovation Spotlight, Marwan A. Alsarraj, global segment manager at Bio-Rad Laboratories, discusses how digital PCR eliminates the need for standard curves while achieving high sensitivity and ...