Proteins are large, complex molecules that carry out the tasks of life. They direct our bodies' activities, organize our thoughts, and defend us against infection, keeping us healthy. But in their ...

Structural mass spectrometry has emerged as a powerful approach to elucidate the three‐dimensional conformations of proteins and their complexes under near‐physiological conditions. In particular, ...

Proteomics arrived on the biotech scene a decade ago, promising a new discovery route to disease markers. Much more complex than genomics, it represents the industrial-scale analysis of the vast array ...

Just like workers need the right environment to efficiently perform their tasks, proteins require placement within specific cellular compartments to function properly. Therefore, understanding where ...

Native Capillary Electrophoresis–Mass Spectrometry Enables Quantitative Profiling of Endogenous Protein Complexes ...

Those hoping to uncover new science may feel disheartened if they struggle with inadequate tools and doubt that more capable tools are within reach. Until recently, such was the case in proteomics.

A typical protein identification workflow using MS involves digesting proteins into peptides and analyzing them using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) on a high-resolution ...

(A) Illustrates the limited understanding of MG1 induced complex stabilization. (B) Schematic representation of MG1 ligation. (C) Enlarged view of the 14-3-3/Pin1/MG1 interface . (D) MG1 covalently ...

BUFFALO, N.Y. ­— Imagine if diagnosis and treatment for devastating conditions such as Alzheimer’s disease could be developed quickly by extensive profiling of protein signatures in human tissues.

Promega Corporation announces the launch of new products for scientists working with mass spectrometry. The IdeS Protease enables fast, easy, high performance digestion of immunoglobulin, while the ...

Daily administration of MGCD265 to patients with solid tumors in a dose-escalation phase I study (study 265-101). Background: To evaluate SELDI as a potential technique for predicting response to ...