Jun 17, 2021 · Primary pyruvate dehydrogenase complex deficiency (PDCD) is a mitochondrial disorder of carbohydrate oxidation that mostly affects the brain and leads to decreased ATP production and …

Pyruvate dehydrogenase deficiency (also known as pyruvate dehydrogenase complex deficiency or PDCD or PDH deficiency) is a rare neurodegenerative disorder associated with abnormal …

Jun 14, 2021 · Learn about Pyruvate Dehydrogenase Complex Deficiency, including symptoms, causes, and treatments. If you or a loved one is affected by this condition, visit.

Pyruvate dehydrogenase deficiency is characterized by the buildup of a chemical called lactic acid in the body and a variety of neurological problems. Signs and symptoms of this condition usually first …

Pyruvate Dehydrogenase Complex Deficiency is a disorder of carbohydrate metabolism caused by a deficiency of one of the three enzymes in the pyruvate dehydrogenase complex (PDC). The age of …

Primary pyruvate dehydrogenase complex deficiency (PDCD) is a mitochondrial disorder of carbohydrate oxidation that mostly afects the brain and leads to decreased ATP production and …

Oct 6, 2025 · Key points • Pyruvate dehydrogenase complex deficiency is a mitochondrial disorder of carbohydrate oxidation that mostly affects the brain and leads to an energy deficit. • Pyruvate …

PDHD is caused by a deficiency of one of the components of the PDH complex. The most common cause are mutations in the PDHA1 gene (Xp22.1), which encodes the E1-alpha subunit.

Carbohydrates are normally broken down into energy by an enzyme in the pyruvate dehydrogenase complex. In people with PDCD, the body does not have enough of these enzymes to break down …

Jun 3, 2025 · The pyruvate dehydrogenase complex of three enzymes is the bridge that gives the body the flexibility to switch from one source of energy to the other. PDC deficiency is a disorder resulting …